And is that even happening, or is it more lower-end jewellery where synthetics are getting the market share?

Source: https://www.marketscreener.com/quote/stock/ANGLO-AMERICAN-PLC-4007113/news/2023-Investor-Update-QA-Transcript-45537300/?utm_medium=RSS&utm_content=20231209

At least two-thirds of all overdose deaths are now linked to illicitly manufactured fentanyl and similar synthetics, not prescriptions.

Source: https://www.nytimes.com/2023/03/25/opinion/adderall-shortage-drug-policy.html

But beyond mushrooms, mycelium – the living, growing feeding part of the fungus organism – is being harnessed to provide low-impact alternatives to animal products, synthetics and electronics.

Source: https://www.theguardian.com/books/2023/mar/19/the-fungal-awakening-how-we-came-to-love-and-fear-fungi

Pharmaceuticals and synthetics are not used.

Source: https://www.healthcanal.com/nutrition/weight-management/best-appetite-suppressant