At the beginning of a playthrough, players have to choose between Gryffindor, Slytherin, Ravenclaw, and Hufflepuff for their school house.

Source: https://gamerant.com/hogwarts-legacy-most-popular-house-slytherin-surprising/

In many ways, Lando seems like a Slytherin.

Source: https://www.deseret.com/entertainment/2023/3/17/23640076/star-wars-characters-hogwarts-houses

Salazar Slytherin would leave many things behind, but his most famous contributions were the Chamber of Secrets and the Basilisk.

Source: https://gamerant.com/harry-potter-hogwarts-founders-explained/

Slytherin is considered the evil house of Harry Potter.

Source: https://gamerant.com/harry-potter-slytherin-considered-evil-house/

The most infamous house that Voldemort used to recruit his Death Eaters and dark wizards from was, of course, Slytherin.

Source: https://www.cbr.com/hufflepuff-no-death-eaters-harry-potter/

The Slytherin student companion Sebastian Sallow in practices dark magic, and the game allows players to either turn him in for his taboo knowledge or not give any report against him.

Source: https://screenrant.com/turn-sebastian-in-or-not-hogwarts-legacy/

This made the Slytherin boy the laughingstock of the school for the very first time.

Source: https://www.cbr.com/harry-potter-draco-malfoy-best-quotes/