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According to GlobalData, only 24 CRISPR-based drugs are in Phase 2 trials, with 88% of such drugs in earlier-stage or preclinical development.
But I would just want to confirm, I think that the preclinical data have been very predictive of what we've seen in humans.
Experimental preclinical research in animals with human-like hearts has proven it's difficult to engineer and transplant stem-cell derived cardiomyocytes that can beat in tandem with surrounding heart tissue for extended periods of time.
Source: https://phys.org/news/2023-03-cyborg-technology-functional-maturation-stem-cell.html
Initial customer milestones show that these technologies can decrease the time and cost of developing new therapies, and de-risk drug portfolios before entering preclinical and clinical stages.
Source: https://vator.tv/news/2023-06-26-digital-health-news-funding-round-up-in-the-prior-week-june-26-2023
In summary, the company continues to be well resourced to execute effective SER-109 commercialization activities pending FDA approval and to drive our ongoing development and preclinical programs.
It is expected that Abeona Therapeutics will release preclinical data from several of the gene therapy programs noted directly above at a medical conference.
Merck KGaA may select molecules for further preclinical and clinical development.
Source: https://medcitynews.com/2023/09/merck-kgaa-expands-in-ai-driven-rd-with-two-drug-discovery-deals/
Preliminary preclinical and clinical data suggest that ONA-XR has anticancer activity by inhibiting progesterone receptor binding to chromatin, downregulating cancer stem cell mobilization, and blocking immune evasion.
This preclinical information demonstrates equal coverage across essential gatekeeper and molecular brake mutations in FGFR2 without any signs of FGFR1-related hyperphosphatemia at effective plasma concentrations.
We are waiting for the PDUFA because once that is done, then we can reference that file for all of the preclinical and safety information.
We're looking forward to presenting detailed results of these preclinical studies at an upcoming conference.
You can find abstracts related to some of this preclinical data on our website.