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At the same time, using the HA exchange system, any assembled integration cassette for overexpression, regardless of its complexity, can be redirected to alternative loci of the genome in two days.
Source: https://phys.org/news/2023-08-dna-kit-crispr-cas9-potential-metabolic.html
This deficiency in type VII collagen leads to extreme skin fragility, chronic blistering and wound formation in these RDEB patients, many of whom go on to develop squamous cell carcinoma frequently metastatic that are driven by overexpression of PLK-1.