An open-label extension study is going in parallel or in all patients opportunity to get treated with ADX71149 in combination with levetiracetam or brivaracetam.

Source: https://seekingalpha.com/article/4627178-addex-therapeutics-ltd-adxn-q2-2023-earnings-call-transcript?source=feed_all_articles

But their deaths occurred after that phase of the trial, when they were knowingly being treated with lecanemab in what’s known as an open-label extension study.

Source: https://www.nytimes.com/2023/01/06/health/alzheimers-drug-leqembi-lecanemab.html

The next catalyst arrives when Cassava provides data from a Cognition Maintenance Study ("CMS") of ~100 patients who continue vs discontinue Simufilam, following 1-year of open-label treatment.

Source: https://seekingalpha.com/article/4580155-cassava-sciences-now-we-wait-but-in-hope-or-expectation?source=feed_all_articles

This multi-center, open-label trial is intended to evaluate the safety, tolerability, pharmacokinetics antitumor activity and pharmacodynamics of 154 in combination with liposomal doxorubicin.

Source: https://seekingalpha.com/article/4582238-shattuck-labs-inc-sttk-q4-2022-earnings-call-transcript?source=feed_all_articles