Her husband has been struck by a mysterious illness, and the only way to brew the cure is with the guts of a Molduga, a monstrous sand serpent that functions as a miniboss fight.

Source: https://screenrant.com/legend-zelda-breath-wild-saddest-side-quests/

Moving forward leads to a miniboss fight against two angels who are weak to Nuke.

Source: https://gamerant.com/persona-5-royal-mementos-depths-walkthrough/

Players can also find a staircase that leads up to an exit back to the Palace entrance, so use it to save the game before tackling the miniboss.

Source: https://gamerant.com/persona-5-royal-futaba-palace-walkthrough/

The Shadow inside is an unavoidable miniboss, so prepare accordingly.

Source: https://gamerant.com/persona-5-royal-nijima-palace-walkthrough/