A total of 441 patients (73 percent with metastases) were randomly assigned in a 2:1 ratio to either GAP or GC and were treated until progression.

Source: https://www.gjsentinel.com/lifestyle/health_and_wellness/nab-paclitaxel-does-not-increase-overall-survival-in-biliary-tract-cancer/article_b692507f-adbf-5b08-bf4b-f745b7915703.html

"Despite chemotherapy, his neuroendocrine prostate cancer progressed resulting in multifocal brain metastases and a likely paraneoplastic ascending paralysis leading to his death," it added.

Source: https://www.ndtv.com/feature/man-in-us-developed-uncontrollable-irish-accent-after-cancer-diagnosis-doctors-say-3792709

“More than a third of patients with MCC present with regional or distant metastases, which are associated with high rates of mortality,” said Dr. Shailender Bhatia, University of Washington and Fred Hutchinson Cancer Center.

Source: https://delawarebusinessnow.com/2023/03/incyte-gets-accelerated-approval-for-skin-cancer-drug/

With data already obtained showing that the, so called "niclosamide stearate prodrug therapeutic" (NSPT) can stop the formation of lung metastases in a mouse model of osteosarcoma, and also actually cure some dogs in a small canine feasibility study.

Source: https://phys.org/news/2023-03-brain-tumor-discovery-paves-drug.html