"Acetaminophen is recommended by doctors as a first-line treatment option for people who have a fever or are experiencing pain during pregnancy.

Source: https://www.marketscreener.com/quote/stock/KENVUE-INC-154055852/news/Lawsuits-claiming-Tylenol-causes-autism-lack-scientific-support-judge-finds-45602518/?utm_medium=RSS&utm_content=20231219

Among patients with protein ligand-1 (PD-L1) expression less than 1%, the ORR was 62% in the first-line setting and 50% in the second-line setting.

Source: https://www.prnewswire.com/news-releases/amgen-presents-new-lumakras-sotorasib-plus-chemotherapy-data-in-first-line-kras-g12c-nsclc-at-wclc-301922393.html

Earlier this year, Impact announced Senaparib met its primary endpoint in a China Phase III trial as a maintenance therapy for ovarian cancer following first-line platinum-based chemotherapy.

Source: https://seekingalpha.com/article/4659466-week-in-review-two-billion-dollar-deals-2023-nears-end-hansoh-gsk-nona-pfizer?source=feed_all_articles

"For instance, the effectiveness of first-line treatment for gonorrhoea continues to be threatened by AMR, demonstrated by cases of extensively-drug-resistant (XDR) gonorrhoea being identified in the UK and many other parts of the world.

Source: https://www.thescottishsun.co.uk/news/11290894/stis-scotland-chlamydia-sex/

I’ll begin by discussing adagrasib, starting with first-line non-small cell lung cancer, where we expect to share key updates across our multipronged development approach in the second half of this year.

Source: https://seekingalpha.com/article/4602314-mirati-therapeutics-inc-mrtx-q1-2023-earnings-call-transcript?source=feed_all_articles

In other PDAC developments in July, we announced the initiation of a randomized Phase 2 combination clinical trial of Motixafortide first-line pancreatic cancer.

Source: https://seekingalpha.com/article/4653194-biolinerx-ltd-blrx-q3-2023-earnings-call-transcript?source=feed_all_articles

No one made Lou pay a career second-line center first-line money.

Source: https://deadspin.com/pro-bowl-skills-competition-las-vegas-future-of-nfl-1850077063

So it's going to be hard to overcome R-CHOP in the first-line with the exception of patients that are high-risk patients.

Source: https://seekingalpha.com/article/4585329-gilead-sciences-inc-gild-presents-cowen-43rd-annual-healthcare-conference-transcript?source=feed_all_articles

This again incorporated BLINCYTO in first-line and showed compared to their extensive historical data, a substantial improvement in overall survival.

Source: https://seekingalpha.com/article/4608560-amgen-inc-amgn-4th-annual-oncology-innovation-summit-insights-for-asco-and-eha-transcript?source=feed_all_articles

While not ruling out hormone blockers as a pathway for some young people, he sees it "as not the first-line intervention as it has been used in a more affirmative way, both in the United States and in the UK".

Source: https://www.bbc.co.uk/news/uk-64683917?at_medium=RSS&at_campaign=KARANGA

WHO is also training health workers on first-line support, provision of post-rape treatment and mental health care to survivors of sexual and gender-based violence (GBV), and is backing national NGOs that provide GBV services.

Source: https://allafrica.com/stories/202306220011.html