Instead of focusing on the main characters, a live-action Simpsons could work by using minor characters as inspiration, like Finn Wolfhard as Milhouse.

Source: https://screenrant.com/the-simpsons-wes-anderson-ai-art-images/

That’s because it’s actually star Finn Wolfhard singing.

Source: https://www.pastemagazine.com/music/young-fathers/best-new-songs-1/

Though Weaver doesn't look to be appearing, most of the cast of Ghostbusters: Afterlife will be back for the yet-to-be-named including Mckenna Grace, Finn Wolfhard, Logan Kim, Celeste O'Connor, Carrie Coon, Paul Rudd, Ernie Hudson, and William Atherton.

Source: https://comicbook.com/movies/news/ghostbusters-star-sigourney-weaver-not-returning-afterlife-sequel/