Most commonly it causes thickening within the fascia of the hand, which is a normal structure that provides attachment of the skin to deeper structures allowing us to use our hands for gripping.

Source: https://www.canberratimes.com.au/story/8366597/what-is-dupuytrens-disease/?src=rss

Now the national charity looks set to move in. It has applied for planning permission to erect advertisements including three non-illuminated fascia signs and one non-illuminated double sided projecting sign.

Source: https://www.coventrytelegraph.net/news/local-news/masterplan-shows-new-future-former-27664509