Enabled by HotSpot's proprietary Smart AllosteryTM platform, HST-1011 is designed with tight binding, low nanomolar potency, a slow dissociation rate from the target to enable sustained pharmacology, and greater selectivity for CBL-B relative to C-CBL.

Source: https://www.prnewswire.com/news-releases/hotspot-therapeutics-to-present-two-poster-presentations-on-cbl-b-program-at-aacr-annual-meeting-2023-301772058.html

His latest captive is Dr. Annabel Mead, a psychiatrist who realizes that Mr. Freeze is suffering from a severe case of dissociation.

Source: https://www.cbr.com/batman-mister-freeze-obsession-dangerous-dc/

‘Returning to a place where trauma has taken place can trigger intense emotional and physiological reactions, causing symptoms such as anxiety, depression, self-harm, dissociation, and even suicidal ideation.’

Source: https://metro.co.uk/2023/03/30/im-moving-home-how-do-i-deal-with-my-annoying-mum-18511561/

Zara suffered panic attacks and periods of dissociation and says she soon came to realise that a combination of her clinically diagnosed anxiety, CPTSD and the impact of childhood trauma were having a grave effect on her life.

Source: https://caerphilly.observer/news/1015284/you-can-relate-to-people-wellbeing-groups-across-caerphilly-help-women-and-men-to-open-up-about-their-mental-health/