Each treatment arm will be compared independently to the placebo arm, and the trial will be determined to be successful if either or both of the cytisinicline treatment arms show a statistical benefit compared to placebo.

Source: https://seekingalpha.com/article/4588117-achieve-life-sciences-inc-achv-q4-2022-earnings-call-transcript?source=feed_all_articles

Given these risks, a treatment with a clean safety profile, like cytisinicline, could potentially offer a more patient-friendly option.

Source: https://seekingalpha.com/article/4607863-achieve-exciting-smoking-cessation-drug-approval-could-come-soon?source=feed_all_articles