However, works as a stand-alone sequel, not relying on prior characters and continuing things via the themes and filmmaking conceits of the first film, like telling the story through a computer screen.

Source: https://screenrant.com/missing-movie-ryan-coogler-helped-sequel-happen/

The first issue sets up the major conceits of the runs so far, setting up the lives of the myriad characters, before dropping the threat of Parasite in, as well as introducing Dr. Pharm and Graft, two new villains.

Source: https://www.cbr.com/best-first-issues-superman-dc-comics/