Another sign can also be unexpected or unintended weight loss.

Source: https://www.hulldailymail.co.uk/news/health/signs-symptoms-bowel-cancer-aware-8336823

Even then, if most of the patients in both groups have mild cognitive impairment, a much slower rate of decline (or perhaps even some continued improvement) for those on simufilam would not be unexpected.

Source: https://seekingalpha.com/article/4592603-biogen-and-eisai-cassava-sciences-and-anavex-clinical-trial-results-in-need-of-revisions?source=feed_all_articles

This would not be unexpected given the market outlook has turned negative again.

Source: https://seekingalpha.com/article/4647756-weis-markets-slow-and-steady-wins-the-race?source=feed_all_articles