Lower extremity Peripheral Arterial Disease (PAD) affects an estimated quarter million adults in and is associated with significant morbidity and mortality, with atherosclerosis being the main cause.

Source: https://www.prnewswire.com/news-releases/concept-medicals-fourth-ide-approval-for-the-magictouch-sirolimus-coated-balloon-is-granted-for-the-treatment-of-superficial-femoral-artery-disease-sfa-301836510.html

Piperine was found to target many processes associated with atherosclerosis.

Source: https://indianexpress.com/article/health-wellness/lower-cholesterol-spice-black-pepper-heart-health-8901658/

The ‘Rocky’ actor’s son died at the age of 36 in 2012 after suffering from coronary heart disease caused by atherosclerosis.

Source: https://hollywoodlife.com/feature/how-did-sage-stallone-die-what-to-know-about-sylvesters-late-son-5183393/