Control then abruptly switches from Batman to his arch-nemesis, The Joker, resulting in some of the very best gameplay in the franchise.

Source: https://gamerant.com/games-that-let-you-play-as-bad-guy/

Just imagine the MCU's Iron Man, infusing Luthor's cold, calculating demeanor with his trademark theatrics and flair, transforming the arch-nemesis of Superman into a figure that is both dangerously genius and unexpectedly human.

Source: https://screenrant.com/robert-downey-jr-superman-movie-canceled/

Venom was an arch-nemesis for Spider-Man.

Source: https://www.cbr.com/spiderman-doctor-octopus-villains-no-longer-big-threats/