One possible explanation for these low response rates is that current treatment approaches do not adequately target anhedonia.

Source: https://www.express.co.uk/life-style/health/1801280/depression-symptoms-anhedonia-meaning-low-mood

Physical anhedonia relates to a loss of enjoyment of physical sensations.

Source: https://www.discovermagazine.com/mind/what-is-anhedonia-and-what-are-the-symptoms-of-this-unique-condition

Progress and challenges in research of the mechanisms of anhedonia in major depressive disorder.

Source: https://www.healthcanal.com/mental-health-behavior/endogenous-depression

Research also shows that having anhedonia predicts of depression.

Source: https://theconversation.com/depression-isnt-just-sadness-its-often-a-loss-of-pleasure-210429

The study conducted on rats showed that animals tolerated the repeated low doses of psilocybin well and did not exhibit signs of reduced pleasure (anhedonia), anxiety, or altered locomotor activity.

Source: https://theshillongtimes.com/2023/10/04/microdoses-of-mushrooms-may-help-fight-mental-disorders-study/

Unfortunately, anhedonia often receives less attention in depression treatment strategies.

Source: https://www.express.co.uk/life-style/health/1801280/depression-symptoms-anhedonia-meaning-low-mood