Dr. Miles Warren slowly built himself up as Spider-Man's next major enemy after the death of Norman Osborn, the Green Goblin.

Source: https://www.cbr.com/spiderman-comics-worst-villains-best-introductions/

Even as a young adult and well into full adulthood, Spider-Man's immaturity tends to shine through at the worst possible moments, making him a real liability in the field.

Source: https://www.cbr.com/worst-things-team-ups-marvel-comics-spiderman/

J. Jonah Jameson is Spider-Man's most ardent naysayer and a famous figure in Spider-Man stories, including the Insomniac games.

Source: https://screenrant.com/all-spider-bots-locations-marvels-spiderman-2/

Making his comic debut all the way back in 1963, The Lizard is one of Spider-Man's most iconic, and often most sympathetic villains.

Source: https://gamerant.com/marvels-spider-man-2-lizard-story-role-curt-connors/

Of course, some may complete a specific Spider-Man's skill tree first because of their affection for the character.

Source: https://gamerant.com/marvels-spider-man-2-sm2-how-bounce-up-enemies-guide/

Spider-Man's amazing powers have helped him spin webs and become a spectacular hero.

Source: https://www.cbr.com/famous-marvel-heroes-weakest-power/

Spider-Man's was actually integrated into the story, featuring a phenomenal range of high-tech functions (including stealth).

Source: https://screenrant.com/every-spider-man-variant-in-across-the-spider-verse/

Spider-Man: The Animated Series offered a unique twist on Spider-Man's powers.

Source: https://www.cbr.com/spider-man-biggest-fears/

The Goblin formula makes Norman Osborn Spider-Man's physical equal and his intellect made him a match for the Avengers when led the Dark Avengers as Iron Patriot.

Source: https://www.cbr.com/xmen-win-vs-marvel-supervillains/

You can almost see the desperation in Spider-Man's hand as he attempts to escape 's grasp.

Source: https://comicbook.com/comics/news/covrprice-top-10-comic-books-rising-value-last-week-jack-white-worlds-finest-star-wars-high-republic/