It seems like this Ghostface is trying to kill the last Woodsboro survivors (though Sidney's absence might make that a bit difficult) for an unknown reason (though, in true fashion, it'll likely relate to horror movie tropes).

Source: https://gamerant.com/scream-6-super-bowl-trailer-ghostface/

Part of why "Scream 3" isn't as scary as the first two is because, by this point, Sidney's almost as much of a threat to the killer as he is to her.

Source: https://www.slashfilm.com/1210346/scream-3-ending-explained-sidney-gets-the-closure-she-needs/

The video shop where Sidney's friend and horror film fanatic, Randy Meeks, works was played by Bradley Video of Santa Rosa, while the remote home that hosts the climatic party massacre is located in Tomales, California.

Source: https://screenrant.com/scream-movies-every-filming-location-woodsboro/