An unlikely friendship with a pregnant woman named Marisol forces him out of the shell he's built to contain the grief from losing his wife, and slowly offers him a reason to connect with A Man Called Otto's in a painful, awkward, and often hilarious way.

Source: https://screenrant.com/man-called-otto-every-version-book-film-differences/

Kraven initially refers to Otto's Ocktoids as "hideous" and calls them a "toy."

Source: https://www.cbr.com/doc-ock-upgrade-spider-man-villain-kraven-the-hunter/