Mirko fights several High-End Nomus alone one of which she destroys very easily.

Source: https://www.cbr.com/mha-war-arc-impressive-heroes/

The lower-tier Nomus are used to carry out expendable attacks whereas the more powerful higher-tier Noums go head-to-head with the heroes as they are seen to be more durable and some are even able to regenerate themselves even after being heavily injured.

Source: https://gamerant.com/my-hero-academia-how-powerful-is-the-league-of-villains/