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Considering Missy's The Big Bang Theory appearance, however, expect that the Cooper twins will eventually patch things up.
Source: https://screenrant.com/young-sheldon-season-6-missy-debut-big-bang-theory/
It's uncertain if this will be Missy's general attitude moving forward.
Source: https://screenrant.com/young-sheldon-season-6-confirm-georgie-missy-tbbt-story/