As a member of the Legendary Sannin, there's no denying that Tsunade Senju is strong, but in comparison to Itachi, her strength withers away.

Source: https://www.cbr.com/naruto-characters-stronger-itachi/

Despite being a mass murderer, Itachi Uchiha has a fascinating fashion sense, even if his younger brother Sasuke Uchiha didn't inherit this.

Source: https://www.cbr.com/inaccurate-spirit-halloween-anime-costumes-2023/

In the end, he was defeated by Itachi Uchiha and his magnificent genjutsu prowess.

Source: https://gamerant.com/naruto-strongest-rogue-ninjas-akatsuki/

Itachi could only manifest a portion of the powers of the Susanoo and still be as menacing as he was.

Source: https://gamerant.com/naruto-strongest-susanoo/

Itachi had awakened the Mangekyou Sharingan in both his eyes, which allowed him to use the Susanoo.

Source: https://gamerant.com/naruto-akatsuki-members-strongest/

Itachi is an INFJ, one of the rarest MBTI types, dedicated to patiently conceptualizing the best ways to help people and transform society.

Source: https://www.cbr.com/myers-briggs-personality-naruto-anime/

Itachi is the older brother of Sasuke Uchiha, as well as one of the strongest shinobi in the series.

Source: https://gamerant.com/naruto-most-intelligent-characters/

Itachi Uchiha has a fairly average height, going from 175.2 cm (~5 ft 9 in) to 178 cm (~5 ft 10 in) between Parts I and II.

Source: https://www.cbr.com/how-tall-are-the-naruto-characters/

That being said, she is weaker than Itachi Uchiha.

Source: https://www.cbr.com/naruto-characters-stronger-itachi/

This episode goes a long way toward making Itachi a fan favorite.

Source: https://screenrant.com/best-naruto-shippuden-episodes/