The Marquis de Gramont having a rags-to-riches type of origin story might also instill within him some genuine anger and even hatred towards John.

Source: https://screenrant.com/john-wick-4-break-franchise-villain-trend/

Though Caine ultimately wins the duel, John tricks the Marquis de Gramont to walking into his path to finish him off, with the Marquis not realizing until it is too late that John still has one more round.

Source: https://screenrant.com/john-wick-villains-fought-how-won/

Though John ultimately dies in his duel with Caine, he still manages to shoot the Marquis de Gramont in the head, with John making peace with Caine and later being buried next to his late wife Helen.

Source: https://screenrant.com/john-wick-4-akira-caine-setup-kill-bill-3-story/

Wick’s antagonist in this movie is Marquis de Gramont — Bill Skarsgård — one of the leaders of the High Table, who uses Caine — Donnie Yen — a blind assassin and martial artist, to eliminate Wick.

Source: https://www.bupipedream.com/ac/136817/john-wick-4-is-a-testament-to-the-series-success/