Getting into Depulso Puzzle Room 2 requires Alohomora, so you need to have helped Hogwarts caretaker Gladwin Moon find hidden Demiguise Statues in Hogwarts, Hogsmeade, and the Highlands.

Source: https://screenrant.com/how-to-find-solve-depulso-puzzle-room-2-hogwarts-legacy/

So long as the player casts Depulso, Accio, or Flippendo just as the Dugbog is charging by, they should be able to flip the Dugbog on its back with relative ease.

Source: https://gamerant.com/hogwarts-legacy-how-flip-dugbog/

Use Depulso on the three blocks on the left to push them toward the back wall.

Source: https://screenrant.com/how-to-find-solve-depulso-puzzle-room-2-hogwarts-legacy/