Horrifying Deadpool concept art from Hugh Jackman's first Wolverine solo movie, X-Men Origins: Wolverine, gets a blunt reaction from Deadpool's co-creator.

Source: https://screenrant.com/deadpool-concept-art-xmen-origins-reaction-rob-liefeld/

While some of Deadpool's jokes can get more elaborate, the character is oftentimes just as funny when not making a reference to another movie, series, or person but actually teasing the characters he's engaging with directly.

Source: https://screenrant.com/deadpool-best-quotes-marvel-movies/